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- W2389002004 abstract "Objective: To study the expression of five multidrug resistance (MDR) genes in hepatocellular carcinoma (HCC) and establish the combined criteria of MDR genes. Methods: Expression of MDR gene mRNA and proteins was detected by using reverse transcriptase polymerase chain reaction (RT-PCR) and flow cytometry respectively. IC50 values of original HCC cells were studied by using MTT method. Results: MDR in HCC was correlated with mdr1, MRP, LRP, TopoⅡα and GSTp1 genes, mdr1 mRNA≥0.5, MRP mRNA≥0.6, LRP mRNA≥0.8, GSTp1 mRNA≥0.7 and TopoⅡα mRNA≤0.4 could be used as combined criteria in MDR status evaluation in HCC. Conclusion: The comples MDR is the main form of HCC drug resistance. Detection of five MDR gene mRAN expression by using RT-PCR technique is necessity and feasibility of predicting the effect of chemotherapy in HCC." @default.
- W2389002004 created "2016-06-24" @default.
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- W2389002004 date "2003-01-01" @default.
- W2389002004 modified "2023-09-23" @default.
- W2389002004 title "Expression and Implication of Multidrug Resistance Genes in Hepatocellular Carcinoma" @default.
- W2389002004 hasPublicationYear "2003" @default.
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