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- W2389007616 abstract "Objective To evaluate the effect and dose-response relationship of salvia miltiorrhiza injection in treating hepatic fibrosis.Methods 168 patients with hepatic fibrosis,who came from two medical centers,were randomly divied into four groups(n=42),three salvia miltiorrhiza injection treatment groups(dose:30,20 and 10 ml/day respectively)and control group.The levels of alanine transaminase(ALT),aspartate aminotransferase(AST),total bilirubin(TB),hyaluronic acid(HA),laminin(LN),procollagen type Ⅲ(PCⅢ),collagen typeⅣ(Ⅳ-C)in the sera were observed respectively,and the changes of symptoms and physical signs and by-effect of treatment were recorded.Results ① Each biochemical indicator of four groups ameliorated significantly after treatment(P0.05).All of hepatic function and hepatic fibrosis indexes of salvia miltiorrhiza injection treatment group at 30 ml dose ameliorated significantly,compared with other groups(P0.05).The ameliorative degree of ALT,AST and LN of 20 ml dose group was better than that of 10 ml dose group and control group(P0.05).The meliorative degree of LN of 10 ml dose group was better than that of control group(P0.05).② The probability of good therapeutic effect in 30 ml dose group increased 4.246 times as compared with control group,and increased 3.068 times as compared with 10 ml dose group.The probability of good therapeutic effect in 20 ml dose group increased 2.356 times as compared with control group.However,there were no statistically significant between 10 ml dose group and control group(P0.05).Conclusion Salvia miltiorrhiza injection could effectivly improve hepatic fibrosis,and there was dose-response relationship." @default.
- W2389007616 created "2016-06-24" @default.
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- W2389007616 date "2011-01-01" @default.
- W2389007616 modified "2023-09-23" @default.
- W2389007616 title "Comparison of Clinical Effect on Treatment of Hepatic Fibrosis by Different Dosages of Salvia Miltiorrhiza Injection" @default.
- W2389007616 hasPublicationYear "2011" @default.
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