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- W2389029606 abstract "A convenient and practical synthetic method for antitumor compound 2-methoxy-N-(3-{4-[3-methyl-4-(6-methyl-pyridine-3-yloxy)phenylamino]quinazolin-6-yl}-E-allyl)acetamide(CP724,714) is accomplished with high overall yields(28%) from 6-methylpyridine-3-ol and high regioselectivity of key step(96:4) based on the Heck coupling reaction which is catalyzed by Pd(OAc)2.Furthermore,the purity of this oncology candidate is 99.8% based on HPLC value." @default.
- W2389029606 created "2016-06-24" @default.
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- W2389029606 date "2008-01-01" @default.
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- W2389029606 title "Synthesis of the antitumor compound CP724,714" @default.
- W2389029606 hasPublicationYear "2008" @default.
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