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- W2389041968 abstract "Objective To explore the effects and clinical curative effects of rosuvastatin on carotid atherosclerosis(CAS) in patients with essential hypertension(EH) through the observation of changes of carotid artery intima-media thickness(CAIMT), blood lipid and blood pressure by rosuvastatin in the treatment of EH. Methods 128 patients with EH were selected as research subjects and CAIMT values, blood pressure and blood lipid were monitored before and after the treatment. Color Doppler ultrasound was used to measure the CAIMT values. The patients were assigned to two groups based on CAIMT values and received regular treatment and rosuvastatin respectively. Clinical effects were observed six months after treatment. Results(1)79 in 128 patients with EH had CAIMT value 1.0mm(61.72%), indicating the thickening of intima-media.(2)The differences of blood lipid levels between the two groups before treatment were not statistically significant(P 0.05). Six months after treatment, the difference of blood lipid change in the group with CAIMT thickening(with the treatment of rosuvastatin) was statistically significant(P 0.01), and CAIMT value significantly decreased(t=7.902, P 0.01); the difference of blood lipid change in the group with no CAIMT thickening(with regular treatment) was not statistically significant(P 0.05), but CAIMT value significantly increased(t=3.017,P 0.01).(3)The significant efficiency and total effective rate in the group with CAIMT thickening received the treatment of rosuvastatin(73.4%, 93.7%) were significantly higher than those in the group with no CAIMT thickening(47.0%, 65.4 %),x2=16.228,19.530,P 0.01. Conclusion Rosuvastatin helps improve the blood lipid level and vascular endothelial cells function of the patients with EH so as to control or alleviate the development of atherosclerosis, and thus improve clinical effects." @default.
- W2389041968 created "2016-06-24" @default.
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- W2389041968 date "2014-01-01" @default.
- W2389041968 modified "2023-09-23" @default.
- W2389041968 title "Observation of the effects and clinical curative effects of rosuvastatin on carotid atherosclerosis in patients with essential hypertension" @default.
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