Matches in SemOpenAlex for { <https://semopenalex.org/work/W2389045844> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2389045844 abstract "A single dose(5mg·kg~(-1)) of sparfloxacin was given to experimentally induced E.coli-MG chickens by oral and intravenous injection.The drug concentration in plasma was detected with HPLC and the pharmacokinetics parameters were analyzed with MCPKP.The results showed that the blood concentration-time curves after oral administration were best described by a two compartment open model with first-order absorption rate.The main pharmacokinetic parameters were as follows: t_(1/2)α 1.7208h,t_(1/2)β13.1773h,t_(max) 0.9083h,C_(max) 0.6198(g·mL~(-1),AUC 3.9161mg·L~(-1)·h~(-1).After intravenous administration,the plasma concentration-time data of sparfloxacin in ill chickens was fitted to a two compartment open model without absorption,and the main pharmacokinetic parameters were as follows: t_(1/2)α 0.4442h,t_(1/2)β 4.7557h,AUC 8.3274mg·L~(-1)·h~(-1).Kel 0.5608h~(-1),V_d 4.1204L·Kg~(-1),AUC 8.3274mg·L~(-1)·h~(-1),Cl_B 0.6004L·Kg~(-1)·h~(-1).The oral bioavailability of sparfloxacin in the ill model chickens was 47.03%." @default.
- W2389045844 created "2016-06-24" @default.
- W2389045844 creator A5031283367 @default.
- W2389045844 creator A5034657959 @default.
- W2389045844 creator A5055061028 @default.
- W2389045844 creator A5066560106 @default.
- W2389045844 creator A5091909297 @default.
- W2389045844 date "2006-01-01" @default.
- W2389045844 modified "2023-09-23" @default.
- W2389045844 title "Pharmacokinetics and Bioavailability of Sparfloxacin in Experimentally Induced E.coli-Mycoplasma Ill Chickens" @default.
- W2389045844 hasPublicationYear "2006" @default.
- W2389045844 type Work @default.
- W2389045844 sameAs 2389045844 @default.
- W2389045844 citedByCount "0" @default.
- W2389045844 crossrefType "journal-article" @default.
- W2389045844 hasAuthorship W2389045844A5031283367 @default.
- W2389045844 hasAuthorship W2389045844A5034657959 @default.
- W2389045844 hasAuthorship W2389045844A5055061028 @default.
- W2389045844 hasAuthorship W2389045844A5066560106 @default.
- W2389045844 hasAuthorship W2389045844A5091909297 @default.
- W2389045844 hasConcept C112705442 @default.
- W2389045844 hasConcept C121332964 @default.
- W2389045844 hasConcept C125287762 @default.
- W2389045844 hasConcept C176947019 @default.
- W2389045844 hasConcept C181389837 @default.
- W2389045844 hasConcept C185592680 @default.
- W2389045844 hasConcept C24890656 @default.
- W2389045844 hasConcept C2777056448 @default.
- W2389045844 hasConcept C2778049240 @default.
- W2389045844 hasConcept C2778512257 @default.
- W2389045844 hasConcept C2780926990 @default.
- W2389045844 hasConcept C3020079912 @default.
- W2389045844 hasConcept C501593827 @default.
- W2389045844 hasConcept C55493867 @default.
- W2389045844 hasConcept C71924100 @default.
- W2389045844 hasConcept C76318530 @default.
- W2389045844 hasConcept C98274493 @default.
- W2389045844 hasConceptScore W2389045844C112705442 @default.
- W2389045844 hasConceptScore W2389045844C121332964 @default.
- W2389045844 hasConceptScore W2389045844C125287762 @default.
- W2389045844 hasConceptScore W2389045844C176947019 @default.
- W2389045844 hasConceptScore W2389045844C181389837 @default.
- W2389045844 hasConceptScore W2389045844C185592680 @default.
- W2389045844 hasConceptScore W2389045844C24890656 @default.
- W2389045844 hasConceptScore W2389045844C2777056448 @default.
- W2389045844 hasConceptScore W2389045844C2778049240 @default.
- W2389045844 hasConceptScore W2389045844C2778512257 @default.
- W2389045844 hasConceptScore W2389045844C2780926990 @default.
- W2389045844 hasConceptScore W2389045844C3020079912 @default.
- W2389045844 hasConceptScore W2389045844C501593827 @default.
- W2389045844 hasConceptScore W2389045844C55493867 @default.
- W2389045844 hasConceptScore W2389045844C71924100 @default.
- W2389045844 hasConceptScore W2389045844C76318530 @default.
- W2389045844 hasConceptScore W2389045844C98274493 @default.
- W2389045844 hasLocation W23890458441 @default.
- W2389045844 hasOpenAccess W2389045844 @default.
- W2389045844 hasPrimaryLocation W23890458441 @default.
- W2389045844 hasRelatedWork W1489015605 @default.
- W2389045844 hasRelatedWork W2347852941 @default.
- W2389045844 hasRelatedWork W2361918808 @default.
- W2389045844 hasRelatedWork W2364067787 @default.
- W2389045844 hasRelatedWork W2364662984 @default.
- W2389045844 hasRelatedWork W2365800490 @default.
- W2389045844 hasRelatedWork W2366647944 @default.
- W2389045844 hasRelatedWork W2367965973 @default.
- W2389045844 hasRelatedWork W2371166883 @default.
- W2389045844 hasRelatedWork W2371395769 @default.
- W2389045844 hasRelatedWork W2372647845 @default.
- W2389045844 hasRelatedWork W2374439883 @default.
- W2389045844 hasRelatedWork W2377406212 @default.
- W2389045844 hasRelatedWork W2380833534 @default.
- W2389045844 hasRelatedWork W2385855764 @default.
- W2389045844 hasRelatedWork W2386645652 @default.
- W2389045844 hasRelatedWork W2389091140 @default.
- W2389045844 hasRelatedWork W2389614085 @default.
- W2389045844 hasRelatedWork W256730222 @default.
- W2389045844 hasRelatedWork W3142128585 @default.
- W2389045844 isParatext "false" @default.
- W2389045844 isRetracted "false" @default.
- W2389045844 magId "2389045844" @default.
- W2389045844 workType "article" @default.