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- W2389052015 abstract "Objective To investigate the possible mechanisms of decreasing steroidogenic function in the aged rat testes through determining the effects of aging on the steady-state levels of the mRNAs of testicular steroidogenic acute regulatory protein (StAR) and 17β-hydroxysteroid dehydrogenase(17β-HSD), and observing the morphology of the testes in the aged male rats. Methods The young male rats and old male rats were treated with human chorionic gonadotropin( hCG) continuously for three times and then the rat serum testosterone (T) levels and the mRNA levels of StAR, 17β-HSDⅢ were determined respectively by chemiluminescent enzyme immunoassay(CLIA) and RT-PCR. At the same time, the morphology of testis interstitial tissue and Leydig cells were studied under light microscope and electronmicroscope. Results (1)The levels of serum T and 17β-HSD Ⅲ mRNA of aged SD rats decreased significantly before and after hCG stimulation, and the StAR mRNA level in aged testes was similar to that in young testis. (2) The appearance of testis in aged SD rat was gloomy and loose in texture. In contrast to the testis of young rats, the number of fibroblasts in the testis interstitial tissue of the aged rat was significantly increased and the number and the size of Leydig cells were significandy decreased. Leydig cells in aged rats exhibited retrograde changes. The treatment of hCG had no effect on the morphological appearance of Leydig cells in both aged and young rats. Conclusion The morphological abnormalities of Leydig cells from aged testis and the reduction in the level of 17β-HSD Ⅲ are contributive to the age-related hypogonadism." @default.
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- W2389052015 date "2006-01-01" @default.
- W2389052015 modified "2023-09-27" @default.
- W2389052015 title "The changes of steroidogenic enzymes and Leydig cell morphology in aged rat testis" @default.
- W2389052015 hasPublicationYear "2006" @default.
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