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- W2389059082 abstract "Objective To explore the effects of exogenous hepatocyte growth factor (HGF) on cardiomyocytes in acute myocardial infarction (AMI) rabbits. Methods Rabbit model of ligated proximal left anterior descending coronary artery (LAD) was used. Thirty six rabbits were randomly divided into three groups: sham operation (SO), control (CG) and intervention (IG) groups. The animals in sham operation and control groups were intravenously infused with normal saline, but those in the intervention group were intravenously administered with HGF (2 mg·kg -1 ·h -1 ). At 48 h after ligated LAD, the hemodynamic studies were performed in each group, and ischemic area and the infarct size were also measured. Cell apoptosis was detected by TUNEL straining, and the expressions of bcl 2, ERK1 and pERK1 proteins were analyzed by Western blotting. Results ① The infarct size in the intervention group was significantly smaller than that in the control group ( P =0.002), and the left ventricular function was improved. ② The myocardial apoptotic index in the intervention group was significantly lower than that in the control group ( P =0.02). ③ The expression of bcl 2 proteins in the intervention group was significantly higher than that in the control group. Exogenous HGF could promote the expression of bcl 2 proteins. No significant difference in the expression of ERK1 was not found between the groups, but the expression of pERK1 in the intervention group increased significantly as compared with that in the control group. Conclusion Exogenous HGF can decrease infarct area, inhibit cardiomyocyte apoptosis and improve left ventricular function. The mechanism may probably be associated with the promotion of the expression of antiapoptotic bcl 2 proteins. As one of signal transduction pathways, phosphorylation of ERK1 is associated with the HGF cardioprotection." @default.
- W2389059082 created "2016-06-24" @default.
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- W2389059082 date "2004-01-01" @default.
- W2389059082 modified "2023-09-25" @default.
- W2389059082 title "Effects of hepatocyte growth factor on cardiomyocytes in AMI rabbits" @default.
- W2389059082 hasPublicationYear "2004" @default.
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