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- W2389065610 abstract "Strontium ranelate is a novel antiosteoporotic agent. Differently with previous antiosteoporotic drugs, it has unique dual effects on bone metabolism, the effects of inhibition on bone resorption and stimulation on bone formation. Although the mechanism of action is still under rigorous research, strontium ranelate stimulates preosteoblast proliferation, differentiation and bone matrix synthesis in rat or mouse culture system. In contrast, it decreases osteoclastic cell differentiation and resorbing activity, and increases osteoclast apoptosis. In vivo, strontium ranelate can increase bone formation,reduce bone resorption and improve bone microstructure in normal mice or rats. In ovariectomized rats, strontium ranelate decreases bone resorption but maintains high bone formation, resulting in increased bone mass and strength. In clinical trial, strontium ranelate can increase the level of serum alkaline phosphatase (bone formation marker) and decrease the level of serum type I collagen C-telopeptide crosslink (bone resorption marker). In histomorphometric analysis, the osteoblast surface and mineral apposition rate increased whereas bone resorption parameters decreased in strontium ranelate treated patients. The treatment with strontium ranelate reduces the risk of new fracture in vertebral and non-vertebral. Those preclinical and clinical data indicate that strontium ranelate is safe and effective antiosteoporotic drug. Its dual effects on induction of bone formation and reduction of bone resorption may make strontium ranelate ideal candidate for antiosteoporosis." @default.
- W2389065610 created "2016-06-24" @default.
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- W2389065610 date "2008-01-01" @default.
- W2389065610 modified "2023-09-26" @default.
- W2389065610 title "Strontium ranelate:Novel paradigm in treatment of osteoporosis" @default.
- W2389065610 hasPublicationYear "2008" @default.
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