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- W2389071700 abstract "Objective: To explore if cytoplasmic nonaggregated mutant huntingtin (Htt) influence differentiation of the neural cell. Methods: By using calcium phosphate precipitation method, cultured neuroblastoma N2a cells were transiently or stably and the effect of mutant huntingtin on the growth of the neurite of N2a cell transfected with cDNA coding amino terminal fragments of normal or mutant huntingtin caused by the stimulation of retinoic acid (RA) or serum free culture was observed. Results: In transiently transfected N2a cells that expressed amino fragments of normal huntingtin containing 20 glutamine repeats (20Q), 20Q was diffusely distributed in the cytoplasm, whereas in most of cells that expressed mutant huntingtin containing 150 glutamine repeats (150Q), aggregates of the mutant Htt were formed in the cytoplasm. On the other hand, in some clones of stably transfected N2a cells expressing 150Q, the mutant Htt was diffused in the cytoplasm, no or few, if any, aggregates being formed, which was similar to normal huntingtin in the cells that stably expressed 20Q. It was notable that after stimulation with retinoic acid (RA) or serum deprivation, the growth of the neurites of both transient cells that contained aggregated mutant huntingtin and stable cells that expressed non aggreagated mutant huntingtin only in the cytoplasm was significantly worse than cells expressing normal huntingtin, whatever normal huntingtin was transiently or stably transfected. Conclusion: Cytoplasmic nonaggregated mutant huntingtin can also influence differentiation of neural cell." @default.
- W2389071700 created "2016-06-24" @default.
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- W2389071700 date "2004-01-01" @default.
- W2389071700 modified "2023-09-23" @default.
- W2389071700 title "Cytoplasmic non-aggregated mutant huntingtin influencing differentiation of neural cell" @default.
- W2389071700 hasPublicationYear "2004" @default.
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