Matches in SemOpenAlex for { <https://semopenalex.org/work/W2389071788> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2389071788 abstract "OBJECTIVE:To investigate the growth inhibition of sodium butyrate on human endometrial cancer and to gain an insight into the possible underlying pathways.METHODS:Human endometrial cancer cell line (HHUA) was seeded in the subcutaneous and implanted in a xenograft model by using nude mice. Then they were randomly divided into two groups and treated with sodium butyrate (for experimental groups) and PBS (for control groups) for up to 4-6 weeks. Tumor size was measured in 2 dimensions at regular time-intervals and tumors, hearts, livers and kidneys were harvested at the end of treatment. Tumor sections were examined by HE staining, electron microscope and TUNEL method. Heart sections, liver sections and kidney sections were examined by HE staining for assessment of toxicity.RESULTS:All the nude mice grew in a good condition. There were no abnormal changes in heart sections, liver sections and kidney sections examined under a light microscope and no toxic reactions during treatment. Tumors decreased in size during sodium butyrate-treatment, but increased in size in the control groups. There were a lot of cell underwent apoptosis in the sodium butyrate-treated groups. TUNEL method demonstrated that apoptotic rate in the sodium butyrate-treated groups was significantly higher than that in the untreated control groups,P0.01. CONCLUSIONS:NaB can significantly inhibit the tumor growth in nude mice bearing HHUA endometrial cancer cells. Its mechanism may be closely related to inducing apoptosis in tumor cells. There are no toxicity to heart, liver and kidney at a treatment dose." @default.
- W2389071788 created "2016-06-24" @default.
- W2389071788 creator A5005244586 @default.
- W2389071788 date "2005-01-01" @default.
- W2389071788 modified "2023-09-25" @default.
- W2389071788 title "Growth inhibition effect of sodium butyrate on human endometrial cancer cells in vivo" @default.
- W2389071788 hasPublicationYear "2005" @default.
- W2389071788 type Work @default.
- W2389071788 sameAs 2389071788 @default.
- W2389071788 citedByCount "0" @default.
- W2389071788 crossrefType "journal-article" @default.
- W2389071788 hasAuthorship W2389071788A5005244586 @default.
- W2389071788 hasConcept C100544194 @default.
- W2389071788 hasConcept C121608353 @default.
- W2389071788 hasConcept C126322002 @default.
- W2389071788 hasConcept C134018914 @default.
- W2389071788 hasConcept C142724271 @default.
- W2389071788 hasConcept C150903083 @default.
- W2389071788 hasConcept C178790620 @default.
- W2389071788 hasConcept C185592680 @default.
- W2389071788 hasConcept C190283241 @default.
- W2389071788 hasConcept C196795494 @default.
- W2389071788 hasConcept C207001950 @default.
- W2389071788 hasConcept C2776979534 @default.
- W2389071788 hasConcept C2777088508 @default.
- W2389071788 hasConcept C2778942008 @default.
- W2389071788 hasConcept C2779707156 @default.
- W2389071788 hasConcept C2780091579 @default.
- W2389071788 hasConcept C2780278673 @default.
- W2389071788 hasConcept C29730261 @default.
- W2389071788 hasConcept C502942594 @default.
- W2389071788 hasConcept C537181965 @default.
- W2389071788 hasConcept C54355233 @default.
- W2389071788 hasConcept C55493867 @default.
- W2389071788 hasConcept C71924100 @default.
- W2389071788 hasConcept C81885089 @default.
- W2389071788 hasConcept C86803240 @default.
- W2389071788 hasConceptScore W2389071788C100544194 @default.
- W2389071788 hasConceptScore W2389071788C121608353 @default.
- W2389071788 hasConceptScore W2389071788C126322002 @default.
- W2389071788 hasConceptScore W2389071788C134018914 @default.
- W2389071788 hasConceptScore W2389071788C142724271 @default.
- W2389071788 hasConceptScore W2389071788C150903083 @default.
- W2389071788 hasConceptScore W2389071788C178790620 @default.
- W2389071788 hasConceptScore W2389071788C185592680 @default.
- W2389071788 hasConceptScore W2389071788C190283241 @default.
- W2389071788 hasConceptScore W2389071788C196795494 @default.
- W2389071788 hasConceptScore W2389071788C207001950 @default.
- W2389071788 hasConceptScore W2389071788C2776979534 @default.
- W2389071788 hasConceptScore W2389071788C2777088508 @default.
- W2389071788 hasConceptScore W2389071788C2778942008 @default.
- W2389071788 hasConceptScore W2389071788C2779707156 @default.
- W2389071788 hasConceptScore W2389071788C2780091579 @default.
- W2389071788 hasConceptScore W2389071788C2780278673 @default.
- W2389071788 hasConceptScore W2389071788C29730261 @default.
- W2389071788 hasConceptScore W2389071788C502942594 @default.
- W2389071788 hasConceptScore W2389071788C537181965 @default.
- W2389071788 hasConceptScore W2389071788C54355233 @default.
- W2389071788 hasConceptScore W2389071788C55493867 @default.
- W2389071788 hasConceptScore W2389071788C71924100 @default.
- W2389071788 hasConceptScore W2389071788C81885089 @default.
- W2389071788 hasConceptScore W2389071788C86803240 @default.
- W2389071788 hasLocation W23890717881 @default.
- W2389071788 hasOpenAccess W2389071788 @default.
- W2389071788 hasPrimaryLocation W23890717881 @default.
- W2389071788 hasRelatedWork W2010280862 @default.
- W2389071788 hasRelatedWork W2089180563 @default.
- W2389071788 hasRelatedWork W2094121299 @default.
- W2389071788 hasRelatedWork W2171817384 @default.
- W2389071788 hasRelatedWork W2350790671 @default.
- W2389071788 hasRelatedWork W2361124873 @default.
- W2389071788 hasRelatedWork W2369273274 @default.
- W2389071788 hasRelatedWork W2369571761 @default.
- W2389071788 hasRelatedWork W2417592528 @default.
- W2389071788 hasRelatedWork W2430684039 @default.
- W2389071788 hasRelatedWork W2464767346 @default.
- W2389071788 hasRelatedWork W2883051989 @default.
- W2389071788 hasRelatedWork W2885949600 @default.
- W2389071788 hasRelatedWork W3028699646 @default.
- W2389071788 hasRelatedWork W3029563487 @default.
- W2389071788 hasRelatedWork W3031702341 @default.
- W2389071788 hasRelatedWork W3032140036 @default.
- W2389071788 hasRelatedWork W3032447215 @default.
- W2389071788 hasRelatedWork W3139691902 @default.
- W2389071788 hasRelatedWork W3149621156 @default.
- W2389071788 isParatext "false" @default.
- W2389071788 isRetracted "false" @default.
- W2389071788 magId "2389071788" @default.
- W2389071788 workType "article" @default.