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- W2389072775 abstract "Objective To evaluate the effectiveness of integrated and intensified interventions on increasing methadone dose among clients of methadone maintenance treatment(MMT) in China.Methods Sixty MMT clinics were selected,stratified by province,and matched by size and HIV prevalence,then were randomly assigned into intervention or control group.Integrated and intensified interventions were implemented in the intervention group and routine MMT services were provided in the control group.Mixed-effect model and multiple logistic regression analysis were used to evaluate the effectiveness of integrated and intensified interventions on increasing methadone dose.Results A total of 6 631 participants were enrolled,of whom 3 797 were in the intervention group and 2 834 were in the control group.Mean daily methadone dose increased from 64.1±35.4(mg/d) to 68.9±38.2(mg/d) in the intervention group,while that increased from 61.4±33.6(mg/d) to 63.3±34.1(mg/d) in the control group.Mixed effects model showed significant differences between the two groups when demographic factors were controlled(F=48.69,P0.0001).The proportion of participants who increased mean daily dose of methadone was 58.8% and 53.5% in the intervention group and the control group,respectively(χ2=34.78,P0.001).Multiple logistic regression analysis showed that integrated and intensified interventions were related to the increase of mean daily methadone dose(OR=1.236,95%CI:1.119～1.364).Conclusion Integrated and intensified interventions exert some effect on increasing mean daily dose of methadone,but not dramatic,and the reason needs further study." @default.
- W2389072775 created "2016-06-24" @default.
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- W2389072775 date "2011-01-01" @default.
- W2389072775 modified "2023-09-23" @default.
- W2389072775 title "Effectiveness of integrated and intensified interventions on increasing methadone dose among clients of methadone maintenance treatment (MMT) in China" @default.
- W2389072775 hasPublicationYear "2011" @default.
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