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- W2389074144 abstract "Objective To investigate the function of large conductance Ca2+-activated K+ channel(BKCa) in vascular smooth muscle cells of rats with insulin resistance(IR) induced by a high-fat and high-sugar diet.Methods The present study investigated the BKCa current and subunit expressions in smooth muscle cells from aortas and mesenteric arteries of IR group and normal control group rats by the whole-cell patch clamp,Western blot and real-time PCR methods.Results BKCa current density was decreased in smooth muscle cells of aortas and mesenteric arteries in IR group.Compared with that in normal control group,peak BKCa current at +60mV was significantly decreased after iberiotoxin perfusion at 100nmol/L(both P0.01).BKCa β1-subunit expression at the mRNA level and protein level was significant decreased in IR group compared with that in normal control group (P0.05).Conclusion Our results suggest that BKCa is decreased both in macrovessels and microvessels in insulin resistance rats.These changes may be related to the down-regulation of β1 subunit expression." @default.
- W2389074144 created "2016-06-24" @default.
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- W2389074144 date "2011-01-01" @default.
- W2389074144 modified "2023-09-24" @default.
- W2389074144 title "Effects of insulin resistance on the function of BK_(Ca) in vascular smooth muscle cells of rats" @default.
- W2389074144 hasPublicationYear "2011" @default.
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