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- W2389078399 abstract "Objective:To evaluate the effects and toxicity of brucine(B)versus brucine lipo- some(BL)against transplant tumor growth.Methods:ICR male mice(18～22 g)were inoculated hep- atocarcinoma Heps cells.The Heps mice were randomly administered with B(1.61,3.23 or 6.46 mg·kg~(-1)·d~(-1),ip)or BL(1.61 or 3.23 mg·kg~(-1)·d~(-1)in B weight,ip)for 8 days.The effectiveness was assessed based on tumor inhibitory ratio and survive time of mice with transplant Heps tumors.The toxici- ty was evaluated by measurements of the mice weight,immune organ weight,blood cell index(leuko- cyte,erythrocyte,platelet,and hemachrome protein,and hepatic function index(ALT and AST)and renal function index(BUN)of the Heps mice.Results:The B and BL showed an inhibition rate of 35.05%(1.61 mg·kg~(-1)·d~(-1)),43.70%(3.23 mg·kg~(-1)·d~(-1))and 46.09%(6.46 mg·kg~(-1)·d~(-1))versus 45.41%(1.61 mg·kg~(-1)·d~(-1))and 58.19%(3.23 mg·kg~(-1)·d~(-1)),respectively,against Heps tumor growth.B and BL were found no significant difference in the prolongation of the life of Heps mice.B and BL enhanced the mice weight and immune organ index and improve the blood cell index and hepatic/re- nal function index.Conclusion:The brucine liposome was more superior and less toxic to bucine in the inhibition of tumor growth in Heps mice,suggesting that it is worthy to have a further investigation to con- firm its anticancer activities." @default.
- W2389078399 created "2016-06-24" @default.
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- W2389078399 date "2006-01-01" @default.
- W2389078399 modified "2023-10-01" @default.
- W2389078399 title "Anticancer effect and toxicity of brucine and brucine liposome in mice with transplant Heps tumors in vivo" @default.
- W2389078399 hasPublicationYear "2006" @default.
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