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- W2389081611 abstract "[Objective] The aim was to study the effects of total extract of Dactyicapnos scandens Hutch on the naloxone-precipitated withdrawal syndrome in morphine dependent mice.[Method] Mice were given increasing doses of morphine to produce a physical dependence.Then the withdrawal syndrome precipitated by naloxone was observed 40 min after total extract Dactyicapnos scandens Hutch were given.[Result] At the dose of 150,300 and 600 mg/kg,total extract Dactyicapnos scandens Hutch reduced jumping of mice(P0.05),significantly inhibited writhing of mice(P0.01) and inhibited body weight loss of mice(P0.05) while the 300 and 600 mg/kg dose had significant inhibition(P0.01).At the dose of 150 and 300 mg/kg,total extracts reduced scratch face action of mice(P0.05).The moderate dose group had significant outcome(P0.01).However,the dose of 600 mg/kg could not inhibit scratch face action compare with natural withdrawal team.[Conclusion] Total extract of Dactyicapnos scandens could significantly inhibit withdrawal syndrome in morphine dependent mice." @default.
- W2389081611 created "2016-06-24" @default.
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- W2389081611 date "2011-01-01" @default.
- W2389081611 modified "2023-09-28" @default.
- W2389081611 title "Effects of Total Extract of Dactyicapnos scandens Hutch on Withdrawal Syndrome in Morphine-dependent Mice" @default.
- W2389081611 hasPublicationYear "2011" @default.
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