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- W2389089298 abstract "Objective To investigate the correlation between human leukocyte antigen(HLA) gene polymorphisms and hemolytic disease of the newborn( HDN). Methods Polymerase chain reaction-sequence specific oligonucleotide(PCR-SSO) was used to genotype HLA-A/B/C/DRB1/DQB1 among 117 HDN patients and 112 non-hemolytic disease of newborn( NHDN) patients. The gene frequencies and the disease relative risk( RR) were analyzed in the two groups. Results The gene frequencies of HLA-DQB1*03∶ 01 and HLA-DRB1*12∶ 02 in HDN group were significantly higher than in NHDN group(P 0. 05),and the RR were 1. 721 and 2. 598. The extended haplotype frequency A*11∶ 01-B*13∶ 01-C*03∶ 04-DRB1*12 ∶ 02-DQB1*03 ∶ 01 was significantly higher in HDN group( P 0. 05). The haplotype frequency of DRB1*12∶ 02-DQB1*03∶ 01 was also significantly higher in HDN group(P 0. 05). The total bilirubin of HDN patients who had DRB1*12∶ 02 or DQB1*03 ∶ 01 alleles were significantly higher in NHDN patients( P = 0). Conclusion The HLADQB1*03∶ 01 and HLA-DRB1*12∶ 02 alleles are positively correlated with the incidence of HDN,which maybe the susceptibility genes for HDN." @default.
- W2389089298 created "2016-06-24" @default.
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- W2389089298 date "2014-01-01" @default.
- W2389089298 modified "2023-09-24" @default.
- W2389089298 title "Study on the correlation between human leukocyte antigen gene polymorphisms and hemolytic disease of the newborn" @default.
- W2389089298 hasPublicationYear "2014" @default.
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