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- W2389092272 abstract "OBJECTIVE:To establish RP-HPLC method for the determination of betahistine in human plasma.METHODS:The separation of betahistine was performed on C18 column with a detection wavelength of 261nm.the mobile phase was composed of 0.05mol/L ammonium acetate-acetonitrile-0.3mol/L sodium lauryl sulphate (60∶40∶1.5)with a flow rate of 0.5ml/min.RESULTS:The linear range of betahistine was 24～480ng/ml,the recovery rate was 81.75%～87.99%with the intra-day RSD at 0.60%～4.82%and inter-day RSD at 4.78%～12.15%.CONCLUSION:This method developed in the present study is simple,fast,accurate and reproducible,which can be used as the pharmacokinetic study for betahistine in human body." @default.
- W2389092272 created "2016-06-24" @default.
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- W2389092272 date "2005-01-01" @default.
- W2389092272 modified "2023-10-16" @default.
- W2389092272 title "Determination of Betahistine in Human Plasma by RP-HPLC" @default.
- W2389092272 hasPublicationYear "2005" @default.
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