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- W2389098045 abstract "【Objective】To study the risk factors of thrombosis in patients with malignant lymphoma and to provide experimental evidence for prophylaxis of thrombosis through observing the dynamic change of coagulation parameters and thrombomodulin.【Methods】 The prothrombin time(PT),active partial thromboplastin time(APTT) and the concentration of fibrinogen were detected by magnetic bead method,and the concentration of thrombomodulin was measured by enzyme-linked immunosorbent assay(ELISA).【Results】 During chemotherapy,plasma concentration of thrombomodulin gradually increased,but PT,APTT and plasma concentration of fibrinogen had no change.After administration of cytotoxic medicines,plasma concentration of thrombomodulin decreased to the level before chemotherapy.Both PT and APTT were shorten after chemotherapy and the concentration of fibrinogen increased.These parameters were normalized about a week after administration of cytotoxic medicines.【Conclusion】The hypercoagulable state in patients with malignant lymphoma occurs mainly in a week after administration of cytotoxic medicines,so the period is the best opportunity to prevent thrombosis." @default.
- W2389098045 created "2016-06-24" @default.
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- W2389098045 date "2007-01-01" @default.
- W2389098045 modified "2023-09-23" @default.
- W2389098045 title "Dynamic Change of Coagulation Parameters in Patients with Malignant Lymphoma and Its Clinical Significance" @default.
- W2389098045 hasPublicationYear "2007" @default.
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