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- W2389105904 abstract "AIM To study the effects of levamisole on imidazoline I_2 receptors in brain of rats.METHODS The potency of levamisole binding to imidazoline I_2 receptors in brain of rats was evaluated by using competitive binding as- says,the maximal binding capacity (B_(max))and dissociation constant (K_d)of imidazoline I_2 receptors were measured in long-term treatment of levamisole and in control group by using saturated binding assay.RESULTS Levamisole inhibited the binding of [~3H]idazoxan to imidazoline I_2 receptors,with a IC_(50)(concentration of drug displacing 50%specific bind- ing)of 4.04×10~(-7)mol·L~(-1).The affinity of imidazoline I_2 receptors,labeled by [~3H]idazoxan,was significantly higher in the levamisole group than in control (K_d increased by 63%).CONCLUSION Levamisole can bind to imidazoline I_2 receptors,and long-term administration of levamisole significantly increased the binding affinity of imidazoline I_2 recep- tors." @default.
- W2389105904 created "2016-06-24" @default.
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- W2389105904 date "2007-01-01" @default.
- W2389105904 modified "2023-09-26" @default.
- W2389105904 title "Effects of levamisole on imidazoline I_2 receptors binding assay in brain of rats" @default.
- W2389105904 hasPublicationYear "2007" @default.
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