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- W2389116955 abstract "Objective To compare the insulin resistance and sex hormone-binding globulin(SHBG) level between gestational diabetes mellitus(GDM) and normal women,explore the relationships between insulin resistance,insulin sensitivity and SHBG.Methods Serum SHBG concentrations were measured in 27 women with GDM and 27 normal women(control group).Insulin and C-peptide release curve,serum free testosterone(FT),fasting blood glucose(FBG) and glycosylated hemoglobin(HbA1c) were measured in two groups by radioimmunoassy or enzyme assay methods.Insulin resistance index(HOMA-IR) and insulin sensitivity index(ISI)were calculated.Results (1)The insulin levels at fasting and 120 min,180 min after glucose intolerance were significantly different between the two groups (P0.05);The peak times of insulin release curves were prolonged,the peak values were higher and recovered slower in GDM group than those in control group.(2)The C-peptide levels at 180 min after glucose intolerance were significantly different between the two groups (P0.01);The peak values of C-peptide release curves were also recovered slower in GDM group than those in control group.(3)The levels of SHBG,HOMA-IR,ISI,FT,FBG and HbA1c were significantly different between the two groups (P0.01).(4)The ratio of SHBG/ fasting insulin were negatively correlated with fasting insulin,C-peptide,insulin resistance index(P0.01),and positively correlated with ISI(P0.01).Conclusion Insulin resistance exists in GDM women,their insulin sensitivity and SHBG concentrations are significantly low,SHBG is correlated with insulin level,insulin resistance and insulin sensitivity.The detection of SHBG can help us to evaluate the insulin resistance and to improve the treatment level of GDM women." @default.
- W2389116955 created "2016-06-24" @default.
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- W2389116955 date "2007-01-01" @default.
- W2389116955 modified "2023-09-24" @default.
- W2389116955 title "Correlation Study between Sex Hormone-binding Globulin and Insulin Resistance in Gestational Diabetes Mellitus" @default.
- W2389116955 hasPublicationYear "2007" @default.
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