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- W2389136344 abstract "Objective To observe the effects of mitochondrial-targeted peptide SS-31 on cognitive and mitochondrial functions in a mouse model of sepsis-associated encephalopathy(SAE).Methods Sixty C57BL/6male mice were randomized into 4groups:sham operation+normal saline group(group SN,n=10),sham operation+SS-31group(group SS,n=10),cecal ligation and puncture(CLP)+normal saline group(group CN,n=20),and CLP+SS-31group(group CS,n=20).Mice received an administration of SS-31(5mg/kg)or equal volume saline immediately and once daily for 6consecutive days after operation.Fear conditioning test(FCT)was performed on days 7and 8on the survived mice.The hippocampal tissues were harvested after behavioral tests and homogenized for measuring levels of reactive oxygen species(ROS)and adenosine-5'-triphosphate(ATP).Mitochondria were freshly isolated for measuring enzymes activities of mitochondrial electron transport chain and mitochondrial membrane potential(MMP).Results Compared with group CN,freezing time at 24 hin the context test,activities of complexesⅠandⅢ,ATP and MMP levels increased while ROS level decreased in group SN,SS and CS(P0.05).Compared with group CS,ROS level decreased while ATP and MMP levels and activities of complexesⅠandⅢincreased significantly in group SN and SS(P0.05).Conclusion Consecutive administration of SS-31 can improve cognitive deficits probably via reversing mitochondrial dysfunction in a mouse model of SAE." @default.
- W2389136344 created "2016-06-24" @default.
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- W2389136344 date "2014-01-01" @default.
- W2389136344 modified "2023-09-26" @default.
- W2389136344 title "Effects of mitochondrial-targeted peptide on cognitive and mitochondrial functions in a mouse model of sepsis-associated encephalopathy" @default.
- W2389136344 hasPublicationYear "2014" @default.
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