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- W2389141822 abstract "Objective: To study the plasma pharmacokinetics of avermectin sustained-release injection which was made by ourself over a 70-day period in rabbit. Methods: Avermectin sustained-release injection for rabbits (as a single subcutaneous formulation) was used at a dose of 10 mg/kg. The plasma concentration of avermectin were determined using high-performance liquid chromatography (HPLC) with UV detection method. Pharmacokinetic analysis of avermectin sustained-release injection plasma concentrations was performed using 3p87 program. Results: Plasma concentrations were fitted to an equation corresponding to a two-compartmental model with an absorption phase(weight=1/c+2). That the peak plasma concentration (Cmax) was 35.9 ng/ml, the time to Cmax (Tmax) was 1.43 d, the area under the curve from time 0 to infinity post-injection (AUC) was 560 ng/ml×d. Conclusion: The results indicate that this avermectin sustained-release injection made by ourself has nearly two-month long-acting effect in rabbits." @default.
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- W2389141822 date "2005-01-01" @default.
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- W2389141822 title "Study of pharmacokinetics for avermectin sustained-release injection in rabbit" @default.
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