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- W2389152391 abstract "Objective To investigate the effects of pretreatment with ketamine or parecoxib on postoperative analgesia after remifentanil anesthesia.Methods Sixty general anesthesia patients(ASA ⅠorⅡ) undergoing elective open hysterectomy were randomly divided into 3 groups.All patients received normal saline 5 ml(group N),ketamine 0.5 mg/kg(group K) or parecoxib 0.5 mg/kg(group P) 10 min before anesthesia.Anesthesia was induced and maintained with IV infusion of remifentail at a target plasma concentration of 3 μg/L and propofol at a target plasma concentration of 4 mg/L.All the patients received PCIA with morphine after operation.Additional 1-2 mg morphine was given when the patients' VAS was greater or more than 4.The time when VAS ≥4 happened at the first time,number of VAS score,the time when VAS 4 after morphine treatment,and morphine consumption during the first 2 h after surgery.VAS scores and morphine consumption 30,45,60,90 and 120 min after operation were also recorded.Results Compare with group NS,the time when VAS ≥4 happened at the first time was prolonged and the scores were lower in group K and group P(P 0.05).Morphine consumption was decreased and VAS scores were lower 30,45,60,90,and 120 min after surgery in group K and group P without any difference between them.Conclusion Pretreatment with either ketamine or parecoxib is effective to relieve postoperative hyperalgesia after intravenous anesthesia with propofol and remifentanil." @default.
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- W2389152391 date "2011-01-01" @default.
- W2389152391 modified "2023-09-23" @default.
- W2389152391 title "Effects of pretreatment with ketamine or parecoxib on postoperative hyperalgesia after remi-fentanil anesthesia" @default.
- W2389152391 hasPublicationYear "2011" @default.
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