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- W2389156775 abstract "Objective To evaluate the effect of cytochrome P450 2D6*10( CYP2D6 * 10) polymorphism on the pharmacokinetics of oral nebivolol after single and multiple doses. Methods Fifteen healthy volunteers which were selected according to their CYP2D6* 10 genotype,consisted of 8 of CYP2D6* 1 carriers and 7 of CYP2D6* 10 / * 10 genotypes. All subjects received a single dose of 5 mg and multiple doses( 5 mg·d-1,qd,for 7 days). Nebivolol in plasma were measured by LC-MS / MS. The main pharmacokinetic parameters were calculated by Win Nonlin program. Results The main pharmacokinetic parameters of nebivolol in plasma between CYP2D6 * 1 carriers and CYP2D6 * 10 / *10 genotypes after a single dose were as follows: t1 /2were( 9. 88 ± 5. 47),( 12. 29 ± 6. 19) h,AUCinfwere( 7. 26 ± 5. 88),( 8. 56 ± 5. 20) μg·L-1·h,Cmaxwere( 1. 11 ± 0. 53),( 1. 42 ± 0. 75)μg·L-1,respectively. The main pharmacokinetic parameters of nebivololin plasma between CYP2D6 * 1 carriers and CYP2D6 * 10 / * 10 genotypes after multiple doses were as follows: t1 /2were( 8. 56 ± 2. 38),( 7. 67 ± 4. 75) h,AUCinfwere( 10. 62 ± 5. 62),( 12. 74 ± 7. 40) μg · L-1·h,Cmaxwere( 2. 05 ± 0. 83),( 2. 02 ± 0. 75) μg·L-1,respectively. No significant differences in the pharmacokinetic parameters of nebivolol were found between CYP2D6 * 1 carriers and CYP2D6 * 10 / * 10 genotypes. The clearance of the multiple doses was significantly lower compared with that of single dose in the different genotyped groups. Conclusion CYP2D6* 10 polymorphism has no significant effect on the pharmacokinetics of oral nebivolol after single and multiple doses. The elimination of nebivolol decreases after the multiple doses,which is not affected by CYP2D6* 10 polymorphism." @default.
- W2389156775 created "2016-06-24" @default.
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- W2389156775 date "2015-01-01" @default.
- W2389156775 modified "2023-09-25" @default.
- W2389156775 title "Effect of cytochrome P450 2D6* 10 polymorphism on the pharmacokinetics of oral nebivolol after single and multiple doses" @default.
- W2389156775 hasPublicationYear "2015" @default.
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