Matches in SemOpenAlex for { <https://semopenalex.org/work/W2389159428> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2389159428 abstract "Objective To study the subchronic toxicity of sodium fluoride on the estrogen receptor expression level of female mice.Method 40 ICR mice(female,weight 18 to 20 g)were randomly divided into 4 groups,10 in each group,and exposed to sodium fluoride solution(0 mg/L,1 mg/L 5 mg/L,25 mg/L) from drinking water for 3 months.The fluorine concentrations in bone tissues were detected by fluorine ion selective electrode.The expression levels of ERα,ERβ,IL-6 mRNA were determined by RT-PCR method.Results Weight differences between groups were not statistically significant(P0.05).The organ coefficient of liver in control group was the highest,followed by low-dose group,medium-dose group and high-dose group(46.56±2.46),(47.03±6.25),(45.84±5.90),(42.19±3.89).Compared with control group(4.98±0.25),the organ coefficients of bone in medium-dose and high-dose group(5.46±0.26),(5.46±0.33) were significantly increased(P 0.05).The fluorine concentrations were gradually increased,from control group to high-dose group(711.37±263.83),(998.75±254.87),(1195.21±159.73),(1957.00±273.19) μg /g,and the differences between medium/high-dose group and control group were statistically significant(P0.05).RT-RCR results showed that estrogen receptor expression levels in ovarian tissues decrease with increased dose,and the difference between high-dose group and control group about the expression levels of ERα was statistically significant(P0.05).Conclusions Fluoride can decrease the expression of estrogen receptor in ovarian tissue,and maybe affect the animal reproductive development." @default.
- W2389159428 created "2016-06-24" @default.
- W2389159428 creator A5085338227 @default.
- W2389159428 date "2011-01-01" @default.
- W2389159428 modified "2023-09-23" @default.
- W2389159428 title "Sodium fluoride subchronic poison impact female mice estrogen receptor expression" @default.
- W2389159428 hasPublicationYear "2011" @default.
- W2389159428 type Work @default.
- W2389159428 sameAs 2389159428 @default.
- W2389159428 citedByCount "0" @default.
- W2389159428 crossrefType "journal-article" @default.
- W2389159428 hasAuthorship W2389159428A5085338227 @default.
- W2389159428 hasConcept C121608353 @default.
- W2389159428 hasConcept C126322002 @default.
- W2389159428 hasConcept C134018914 @default.
- W2389159428 hasConcept C170493617 @default.
- W2389159428 hasConcept C178790620 @default.
- W2389159428 hasConcept C179104552 @default.
- W2389159428 hasConcept C185592680 @default.
- W2389159428 hasConcept C2777164284 @default.
- W2389159428 hasConcept C2779234887 @default.
- W2389159428 hasConcept C2780828025 @default.
- W2389159428 hasConcept C29730261 @default.
- W2389159428 hasConcept C530470458 @default.
- W2389159428 hasConcept C537181965 @default.
- W2389159428 hasConcept C71924100 @default.
- W2389159428 hasConcept C84606932 @default.
- W2389159428 hasConceptScore W2389159428C121608353 @default.
- W2389159428 hasConceptScore W2389159428C126322002 @default.
- W2389159428 hasConceptScore W2389159428C134018914 @default.
- W2389159428 hasConceptScore W2389159428C170493617 @default.
- W2389159428 hasConceptScore W2389159428C178790620 @default.
- W2389159428 hasConceptScore W2389159428C179104552 @default.
- W2389159428 hasConceptScore W2389159428C185592680 @default.
- W2389159428 hasConceptScore W2389159428C2777164284 @default.
- W2389159428 hasConceptScore W2389159428C2779234887 @default.
- W2389159428 hasConceptScore W2389159428C2780828025 @default.
- W2389159428 hasConceptScore W2389159428C29730261 @default.
- W2389159428 hasConceptScore W2389159428C530470458 @default.
- W2389159428 hasConceptScore W2389159428C537181965 @default.
- W2389159428 hasConceptScore W2389159428C71924100 @default.
- W2389159428 hasConceptScore W2389159428C84606932 @default.
- W2389159428 hasLocation W23891594281 @default.
- W2389159428 hasOpenAccess W2389159428 @default.
- W2389159428 hasPrimaryLocation W23891594281 @default.
- W2389159428 hasRelatedWork W157493570 @default.
- W2389159428 hasRelatedWork W1578210758 @default.
- W2389159428 hasRelatedWork W2396856571 @default.
- W2389159428 hasRelatedWork W2409034239 @default.
- W2389159428 hasRelatedWork W2409784374 @default.
- W2389159428 hasRelatedWork W2409788406 @default.
- W2389159428 hasRelatedWork W2413688539 @default.
- W2389159428 hasRelatedWork W2430044786 @default.
- W2389159428 hasRelatedWork W2990221326 @default.
- W2389159428 hasRelatedWork W3006030852 @default.
- W2389159428 hasRelatedWork W3028643164 @default.
- W2389159428 hasRelatedWork W3030228960 @default.
- W2389159428 hasRelatedWork W3030644206 @default.
- W2389159428 hasRelatedWork W3032190138 @default.
- W2389159428 hasRelatedWork W3032312810 @default.
- W2389159428 hasRelatedWork W3032392123 @default.
- W2389159428 hasRelatedWork W3083069046 @default.
- W2389159428 hasRelatedWork W3163404672 @default.
- W2389159428 hasRelatedWork W3198156763 @default.
- W2389159428 hasRelatedWork W3032705393 @default.
- W2389159428 isParatext "false" @default.
- W2389159428 isRetracted "false" @default.
- W2389159428 magId "2389159428" @default.
- W2389159428 workType "article" @default.