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- W2389161759 abstract "Objective To investigate the effects of glucagon like peptide 1( GLP-1) on tumor necrosis factor-α( TNF-α),the transform growth factor beta-β1( TGF-β1) and liver oxidative stress in rats with diet-induced non-alcoholic fatty liver disraset. Methods Thirty male SD rats were randomly divided into three groups: ordinary diet group( ND group),high fat diet( HFD group) and high fat diet plus long-term pancreatic liter sugar element man peptide 1( GLP-1) intervention( GLP-1 group). All the rats were killed when fed for 16 weekends. Serum alanine aminotransferase( ALT),TGF-β1,triglycerides( TG),total cholesterol( TC),serum and liver homogenate of liver homogenate superoxide dismutase( SOD),malondialdehyde( MAD) were detected. Results The body quality,serum ALT and liver index,TG,TC,TGF-β1 in HFD group obviously were higher than that of ND group and GLP-1 group( P 0. 05).There was no statistically significant difference between GLP-1 group and ND group( P 0. 05). Serum and liver homogenate of TG,TC,SOD,MDA,TNF-α in alpha HFD group were higher than that in ND group and GLP-1 group( P 0. 05). Compared with ND group,GLP-1 group were slightly higher,but there was no statistical significance( P 0. 05). Conclusion GLP-1 can relieve fatty degeneration of liver of NAFLD,reduce the content of TNF-α and TGF-β1,improve the oxidative stress and lipid peroxidation,suggest using GLP-1 analogues lalu peptide drugs can be used as effective drugs for the treatment of NAFLD." @default.
- W2389161759 created "2016-06-24" @default.
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- W2389161759 date "2014-01-01" @default.
- W2389161759 modified "2023-09-23" @default.
- W2389161759 title "Effects of GLP-1 on TNF-α,TGF-β1 and liver oxidative in rats with non-alcoholic liver disease" @default.
- W2389161759 hasPublicationYear "2014" @default.
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