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- W2389174647 abstract "Objective:To investigate the mechanism of xiezhuo huayu prescription on non-alcoholic fatty liver from the expression of cytochrome P450ⅡE1 and oxidation-antioxidation function changes.Meothods: Using high-fat diet to induce non-alcoholic fatty liver model, the experimental rats were divided into model, xiezhuo huayu prescription high, medium and low dose groups, tiopronin control group and normal control group.To observe liver function,cholesterol (TC), triglyceride (TG) levels changes, test the content of MDA,GSH and superoxide dismutase (SOD) activity,and the histomorphological changes were observed by optical microscope;cytochrome P450Ⅱexpression was determined by immunohistochemical method.Results: To compare with model group, SOD activity and GSH content of rats' livers were significantly increased in three xiezhuo huayu prescription groups,and MDA content was decreased obviously;rats' serum TC, TG level were lowered in each treated group; histomorphological observation showed that the accumulation of lipid droplets in liver tissue was obviously in model group, while the normal group had no accumulation of lipid droplets. the fatty degeneration of liver was improved in three xiezhuo huayu prescription groups; hepatic cytochromeP450ⅡE1 expression was inhibited at different levels in each xiezhuo huayu prescription group.Conclusion: Xiezhuo huayu prescription can protect liver, which maybe by reducing liver cell lipid droplet accumulation, decreasing serum TC, TG content, improving liver function, enhancing the activity of SOD and GSH content in liver tissue and inhibiting P450ⅡE1 expression in non-alcoholic fatty liver rats." @default.
- W2389174647 created "2016-06-24" @default.
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- W2389174647 date "2009-01-01" @default.
- W2389174647 modified "2023-09-27" @default.
- W2389174647 title "XIEZHOU HUAYU PRESCRIPTION ON LIVER PIGMENT P450IIE_1 EXPRESSION AND LIPID PEROXIDATION OF RATS WITH NON-ALCOHOLIC FATTY LIVER" @default.
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