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- W2389180703 abstract "Objective To study effect of sex hormones in the development of rat hepatocellular carcinoma Methods 80 rats were randomly divided into four groups: the first group was the control group,drank mineral water,ate normal feeding,the other 3 groups drank water containing DENA,liquid after was replaced,after 14 weeks DENA was stopped and drank mineral water,in the 3 group were added with diethylstilbestrol,testosterone and armor progesterone respectively,the hepatocellular carcinoma incidence in each group was observed.Results Estrogen,androgen and progesterone group the incidence of liver cancer are: 30%,85% and55% respectively,three groups of liver cancer incidence rate had significant difference(P 0.05).Most of estrogen group still were cirrhosis of the liver in the eighteenth week.However,part rats had appeared liver cancer in the 12th weeks,16 to 18 weeks were cancerous in androgen group.Progesterone group was between the two groups.Conclusion Estrogen in rat liver tumors have stronger inhibition is a protective factor;Progesterone in liver tumors inhibition plays,is a protective factor,Liver cancer is a androgen dependence tumor,androgen in liver tumors contribute in,is a risk factors.But the three types of hormones are not induce lier cancer independent factors or main factors." @default.
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- W2389180703 date "2012-01-01" @default.
- W2389180703 modified "2023-09-23" @default.
- W2389180703 title "Animal experiments of the role of sex hormones in the liver cancer" @default.
- W2389180703 hasPublicationYear "2012" @default.
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