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- W2389181523 abstract "Objective To investigate the changes and the significance of the number of nerve cells and the expression of the postsynaptic density tyrosine kinase(Fyn) in the hippocampus of the rat whose spatial learning and memory function was enhanced by chronic multiple stress. Methods Thirty-nine adult rats were randomly divided into three groups: multiple stressed,single stressed and control group.Rats in the multiple stressed group were irregularly and alternatively exposed to the situation of vertical revolve,sleep expropriate,restraint(6h/d),and night illumination for 6 weeks,to preparate chronic multiple stressed model.Rats in the single stressed group were exposed to restraint only for 6 weeks,6h/d.After that,the performance of spatial learning and memory of all rats was measured using Morris water maze.Nerve cells in different subfields of the hippocampus were observed using Cresyl violet method and counted regardless of size or shape.The expression of Fyn protein and the level of Fyn mRNA in the hippocampus of rats were detected by immunohistochemical method and RT-PCR technique respectively. Results Compared with control group,the performance of spatial learning and memory of rats was increased in multiple stressed group and decreased in single stressed group((P0.05).) The numbers of nerve cells in DG,CAl and CA3 of the hippocampus in both multiple stressed and single stressed group were more than that in control group((P0.05).) The immunoreactivities of Fyn in the stratum radiatum of CA3 region were increased in rats of multiple stressed group and decreased in rats of single stressed group((P0.05).) The level of Fyn mRNA was also up-regulated in the hippocampus of multiple stressed rats and down-regulated in the single stressed rats(P0.05).The performance of spatial learning and memory of rats was positively correlated with Fyn expression.Conclusion Chronic multiple stress can enhance spatial learning and memory function of rats,and increase the number of nerve cells in the hippocampus.The expression of Fyn protein and the level of Fyn mRNA are also increased in the rat hippocampus respectively.These results suggest that Fyn may participate in the process of the enhanced learning and memory by chronic multiple stress." @default.
- W2389181523 created "2016-06-24" @default.
- W2389181523 creator A5037954064 @default.
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- W2389181523 date "2005-01-01" @default.
- W2389181523 modified "2023-09-28" @default.
- W2389181523 title "PROLIFERATION AND EXPRESSION OF HIPPOCAMPAL CELLS AND CHANGE OF POSTSYNAPTIC DENSITY Fyn IN THE HIPPOCAMPUS OF THE RAT WHOSE LEARNING AND MEMORY WAS ENHANCED BY CHRONIC MULTIPLE STRESS" @default.
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