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- W2389186545 abstract "Objectives To observe the changes in oxidative stress and cytokine and the effect of carvedilol intervention in patients with chronic heart failure(CHF) Methods 67 patients with CHF were randomly divided into two groups: control group (n=33), carvedilol group (n=34), received 12-week routine therapy alone or plus carvedilol, respectively. Left ventricular ejection fraction (LVEF), left ventricular end systolic volume index(LVESVl) were measured by echo-Doppler, plasma malondialdehyde, serum superoxide dismutase, tumor necrosis factor-α (TNT-α), interleukin-6 and matrix metalloproteinases-9 (MMP-9) level were assaied also. Results With the progress in NYHA cardiac functional grading, the plasma malondialdehyde, TNF-α, interleukin-6 and MMP-9 levels were increased, SOD decreased significantly (P0.01), After therapy with carvedilol, the plasma malondialdehyde, TNF-α, interleukin-6 and MMP-9 levels were decreased (P0.01), SOD, LVEF increased and LVESVI decreased(P0.05). The increase in LVEF was negative correlation with the decrease in malondialdehyde, TNF-, interleukin-6 and MMP-9, respectively(γ=-0.40, -0.36,-0.38, -0.43,P0.05), positive with SOD (γ=0.38,P0.05). Conclusions Carvedilol improves cardiac function in patients with CHF, it is possibly involved decrease in oxidative stress and cytokine." @default.
- W2389186545 created "2016-06-24" @default.
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- W2389186545 date "2004-01-01" @default.
- W2389186545 modified "2023-09-23" @default.
- W2389186545 title "Changes in oxidative stress and cytokine and the effect of carvedilol intervention in patients with chronic heart failure" @default.
- W2389186545 hasPublicationYear "2004" @default.
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