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- W2389190037 abstract "Objective To study the effects of traditional Chinese herbs Refu Yao on mice models with scleroderma of COL-I and COL-Ⅲ.Methods 60 BALB/C mice models were randomly divided into six groups with ten mice in each group.Mice models with scleroderma were established in mice by repeated local injections of bleomycin for five weeks.Then 10%,20% and 40% Refu Yao were given to the mice models of high-concentration group,mid-concentration group and low concentration group for one month.Than the pathological change of skin tissue was observed,and the COL-I and COL-Ⅲ expression in lesions were detected by immunohistochemical detection.Results Compared with the model group,there was significant improvement in the skin tissue of high-concentration group and mid-concentration group.The content of COL-I and COL-Ⅲ was decreased remarkably by Refu Yao,and the difference was significance(P0.05).Conclusion Refu Yao can take effects on decreasing of the content of COL-I and COL-Ⅲ,and it can also improve fibrosis in the skin." @default.
- W2389190037 created "2016-06-24" @default.
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- W2389190037 date "2011-01-01" @default.
- W2389190037 modified "2023-09-23" @default.
- W2389190037 title "Effects of Refu Yao on Mice Models with Scleroderma of COL-I and COL-III" @default.
- W2389190037 hasPublicationYear "2011" @default.
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