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- W2389194803 abstract "AIM To investigate the effect of tanshinone ⅡA( TanⅡA) on the autophagy of human gastric cancer SGC7901 cells and possible mechanism.METHODS SGC7901 cells were cultured in vitro and incubated with different concentrations( 0.5,1,2,4 μg/mL) TanⅡA in different time( 24,48,72 h).MTT assay was developed to detect the cell proliferation.The cell apoptotic rate and the content of acidic vesicular organelles content were detected by flow cytometry in 48 h.The expressions of autophagy-associated protein Beclin 1,phosphatase and tensin homolog( PTEN),LC3-I and LC3-Ⅱ were detected by real-time RT-PCR and western blot.RESULTS TanⅡA( 0.5 μg/mL) had no significant effect on proliferation of SGC7901 cells compared to DMSO group( P 0.05).Tan Ⅱ A showed a dose-and time-dependent growth inhibition at the concentration above1 μg/mL( P 0.05).Compared with DMSO group,the cell apoptotic rate and content acid vesicular organelles content increased with the treatment of Tan ⅡA.The results of real-time RT-PCR and western blot showed that compared with DMSO group,the expressions of Beclin 1,PTEN and LC3-Ⅱ were significantly up-regulated as well as the experssion of LC3-I was significantly down-regulated( P 0.05).CONCLUSION Tan ⅡA induces the auophagy of human gastric cancer SGC7901 cells in time-and dose-dependent manner in vitro,which may be related to the up-regulation of Beclin 1,PTEN and LC3-Ⅱ,as well as down-regulation of LC3-I." @default.
- W2389194803 created "2016-06-24" @default.
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- W2389194803 date "2014-01-01" @default.
- W2389194803 modified "2023-09-23" @default.
- W2389194803 title "Tanshinone IIA induces autophagy of human gastric cancer SGC7901 cells line in vitro" @default.
- W2389194803 hasPublicationYear "2014" @default.
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