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- W2389200306 abstract "Objective To investigate the role of hypoxia inducible factor-1α (HIF-1α) and von Hippel-Lindau (VHL) in murine endochondral ossification. Methods The knockout of HIF-1α or VHL gene in murine osteoblasts was accomplished by conditional knockout technique at 4th,8th and 12th week,and the differences between wild-type group and knock-out group in endochondral ossification were detected by HE staining,micro-CT scanning,trabecular bone area measurement,calcium content measurement,tetracycline fluorescence labeling,Real-time PCR and Western blotting.Results After knockout of HIF-1α gene in osteoblasts,the expression of vascular endothelial growth factor(VEGF) reduced,the rate of new bone formation stepped down,the content of calcium became less,and the trabecular bone volume decreased ( P 0.05). After knockout of VHL gene in osteoblasts,the expression of VEGF increased,the rate of new bone formation stepped up,the content of calcium became more,and the trabecular bone volume was promoted ( P 0.001).Conclusion During murine endochondral ossification,VHL/HIF-1α signal pathway promotes angiogenesis through the stimulation of VEGF expression,which subsequently accelerates osteogenesis." @default.
- W2389200306 created "2016-06-24" @default.
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- W2389200306 date "2009-01-01" @default.
- W2389200306 modified "2023-09-24" @default.
- W2389200306 title "Role of hypoxia inducible factor-1α and VHL in murine endochondral ossification" @default.
- W2389200306 hasPublicationYear "2009" @default.
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