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- W2389209541 abstract "Objective To explore the therapeutic effect and medication safety of low-dose erythromycin treatment on intractable allergic rhinitis(AR) associated with bronchus asthma.Methods Totally 173 cases of children received outpatient treatment because of AR associated with asthma,their ages ranging from 3 to 14 years.Among them,78 cases developed intractable AR with symptoms of asthma having been controlled or satisfactorily controlled after 2 courses of conventional treatment.Seventy-six children with intractable AR received full follow-up and were randomly divided into observation group and control group.The control group was given different second-generation antihistamines,when necessary,supplemented by nasal glucocorticoids.In the observation group,the same treatment as it was done in control group was continued,plus oral treatment with erythromycin enteric-coated capsules(10 mg·kg-1·d-1,which were taken 3 times a day for 1 month) to the observation group.Both observation group and control group were in accordance with the norms of the treatment of asthma.Results The improvement rate,inefficiency and the total efficiency were different between observation group and control group,and the diffe-rence was statistically significant(χ2=12.629,8.412,8.412,Pa0.005).Comparing the adverse reactions of 2 groups,observation group's appetite was more hyperactive than the control group's(χ2=8.324,P0.005).Differences of other adverse reactions such as irregular abdominal pain,diarrhea,loss of appetite were not statistically significant between observation group and control group(Pa0.05).Their liver function was also monitored and was found normal before treatment and after the replacement of drugs for 1 month,including alanine ami-notransferase,aspartate aminotransferase,albumin,globulin,and were found normal.Conclusions On the basis of conventional treatment,low-dose erythromycin treatment of intractable AR is effective and safe.However,the treatment must be limited to the refractory cases,and the appropriate indications must be strictly observed." @default.
- W2389209541 created "2016-06-24" @default.
- W2389209541 creator A5051813965 @default.
- W2389209541 date "2010-01-01" @default.
- W2389209541 modified "2023-09-27" @default.
- W2389209541 title "Low-Dose Erythromycin Treatment on Intractable Allergic Rhinitis Associated with Bronchus Asthma" @default.
- W2389209541 hasPublicationYear "2010" @default.
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