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- W2389213891 abstract "Objective:To investigate inhibitive the effects of ribozyme on gene expression of tissue inhibitor of metalloproteinase-1(TIMP-1),searching for a new therapeutic strategy for hypertrophic scar.Methods: Human hypertrophic scar derived fibroblasts(HSF) were stably transfected with reconstructed plasmids named pU6-Rz182.G418 was applied to screen the cell clone steadily expressing ribozyme.The transfected cells were examined by MTT to draw the growth curve and evaluate cell growth.The expressions of TIMP-1 mRNA were detected by semi-quantity RT-PCR.Results:Compared with the control group,the expressions of TIMP-1 mRNA in HSF in the Rz182 group and Rzm group were depressed by 87.9% and 36.4%,respectively.There was significant difference between the Rz182 group and the Rzm group(P0.01).The number of living HSF cells at platform interval decreased markedly(P0.01,Rz182 group vs Rzm group and control group),while there was no significant difference between Rzm group and control group.Conclusion:The rebozyme of pU6Rz182 is able to specifically inhibit the expression of TIMP-1 in HSF and the proliferation of HSF." @default.
- W2389213891 created "2016-06-24" @default.
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- W2389213891 date "2005-01-01" @default.
- W2389213891 modified "2023-09-25" @default.
- W2389213891 title "Effect of ribozyme on TIMP-1 expression and proliferation fibroblasts in human skin scars" @default.
- W2389213891 hasPublicationYear "2005" @default.
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