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- W2389239441 abstract "Enzymes from the ribonuclease III family bind and cleave double-stranded RNA to initiate RNA processing and degradation of a large number of transcripts in bacteria and eukaryotes. This chapter focuses on the description of the diverse functions of fungal RNase III members in the processing and degradation of cellular RNAs, with a particular emphasis on the well-characterized representative in Saccharomyces cerevisiae, Rnt1p. RNase III enzymes fulfill important functions in the processing of the precursors of various stable noncoding RNAs such as ribosomal RNAs and small nuclear and nucleolar RNAs. In addition, they cleave and promote the degradation of specific mRNAs or improperly processed forms of certain mRNAs. The cleavage of these mRNAs serves both surveillance and regulatory functions. Finally, recent advances have shown that RNase III enzymes are involved in mediating fail-safe transcription termination by RNA polymerase II (Pol II), by cleaving intergenic stem-loop structures present downstream from Pol II transcription units. Many of these processing functions appear to be conserved in fungal species close to the Saccharomyces genus, and even in more distant eukaryotic species." @default.
- W2389239441 created "2016-06-24" @default.
- W2389239441 creator A5025099474 @default.
- W2389239441 creator A5049057337 @default.
- W2389239441 date "2012-01-01" @default.
- W2389239441 modified "2023-09-25" @default.
- W2389239441 title "The Diverse Functions of Fungal RNase III Enzymes in RNA Metabolism" @default.
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- W2389239441 doi "https://doi.org/10.1016/b978-0-12-404740-2.00010-0" @default.
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