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- W2389246583 abstract "Objective To observe the protective effect of resveratrol (Res) on Parkinson's disease (PD) rats, and explore its potential mechanism. Methods The PD model rats were induced by injecting 6-OHDA into the right striatum in rats, The valid PD rats were randomly divided into four groups: model control group, resveratrol groups (10, 20 and 40 mg/kg/d), sham group and normal administration group (resveratrol 20 mg/kg/d). Res was given orally once daily for 10 weeks, Rotational test was examined weekly during administration. The ultrastructure of substantia nigra tissues was observed by electronic microscope, the levels of caspase-3 mRNA was determined by RT-PCR.Results ①Res could decrease the turns of PD rats. ②Res could alleviate 6-OHDA induced degeneration of dopaminergic neurons in rat substantia nigra. ③Res could decrease the expression of caspase-3 mRNA in rat substantia nigra. Conclusion Res have protective effect on PD model rats, which may be related to down regulation of caspase-3 mRNA." @default.
- W2389246583 created "2016-06-24" @default.
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- W2389246583 date "2009-01-01" @default.
- W2389246583 modified "2023-09-25" @default.
- W2389246583 title "Protective effect of resveratrol on Parkinson's disease rats and its mechanism research" @default.
- W2389246583 hasPublicationYear "2009" @default.
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