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- W2389262786 abstract "Objective To investigate the function of Th17 cells and changes of CD4+CD25+ T regulatory(Treg) cells in children with Henoch-Schonlein purpura(HSP) in acute phase and explore their roles in immunopathogenesis of the disease.Methods Fifty-four patients with HSP were involved in this study,and randomized to HSP-Nephritis(HSPN) group and non-HSPN(NHSPN) group based on a urine analysis.The plasma interleukin-17(IL-17) was measured by ELISA,and CD4+CD25+Treg cells,CD4+cells,CD8+ cells,CD3+ cells,NK cells(CD3-CD56+),B cells(CD19+) and CD3+HLADR+ cells were detected by flow cytometric analysis.Thirty healthy kids were served as controls.Results The plasma level of IL-17 in the sick kids was higher than that in the control(t=14.66,P0.01),while that the difference between HSPN and NHSPN groups was not significant(P0.05).The ratio of CD4+CD25+Treg cells in peripheral blood of the patients was lower than that of the control(t=7.28,P0.01),the difference of that between the HSPN and NHSPN was not significant(P0.05).The level of CD4+CD25+ Treg cells in the sick children was positively correlated with CD4+ cells(r=0.554,P0.01),negatively correlated with CD19+ cells(r=-0.305,P0.05),but not correlated with CD8+,CD3+,CD3-CD56+ and CD3+HLADR+ cells(r=-0.109-0.287,P0.05).Plasma level of IL-17 in the sick children was negatively correlated with CD4+CD25+Treg cells(r=-0.295,P0.05).Conclusion The function of Th17 cells is enhanced and immunosuppression insufficient in patients with HSP,the imbalance of Th17/Treg involves in the process of HSP development." @default.
- W2389262786 created "2016-06-24" @default.
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- W2389262786 date "2012-01-01" @default.
- W2389262786 modified "2023-09-28" @default.
- W2389262786 title "FUNCTION OF Th17 CELLS AND CHANGES OF CD4~+CD25~+T REGULATORY CELLS IN CHILDREN WITH HENOCH-SCHONLEIN PURPURA IN ACUTE PHASE" @default.
- W2389262786 hasPublicationYear "2012" @default.
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