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- W2389276626 abstract "Objective:Preimplantation genetic diagnosis(PGD)by fluorescent in situ hybridization (FISH) on women of advanced maternal age and had procreated a baby with trisomy 21. Methods:The embryos of women of advanced maternal age were biopsied and performed FISH with 21 centromere probe(marked by FITC). The embryos with normal chromosoms number were picked out for transfer. Result:4 embryos were got after routine intracytoplasmic sperm injection (ICSI),3 of them were good embryos. All of the 3 embryos were biopsied and performed FISH.In each blastomrer, 3 signals of 21chromosome were found. To prevent trisomy 21,the transfer were canceled, and the infected babies were pretended from born.Conclusion:Preimplantation genetic diagnosis (PGD) by fluorescent in situ hybridization (FISH) on women of advanced maternal age and had procreated a baby with trisomy 21 is practicable, and necessary. It is a good method to pretend the birth of babies with trisomy 21." @default.
- W2389276626 created "2016-06-24" @default.
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- W2389276626 date "2005-01-01" @default.
- W2389276626 modified "2023-09-26" @default.
- W2389276626 title "Preimplantion genetic diagnosis with 21 chromosome probe on women of advance maternal age" @default.
- W2389276626 hasPublicationYear "2005" @default.
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