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- W2389291257 abstract "Objective: How to prepare the ideal scaffold has been a focal point in the bone tissue engineering.At present,the most used scaffolds are natural scaffolds,synthetic organic and inorganic scaffolds.The bio-derived cancellous bone scaffold is one of the natural scaffold materials.Because of its natural bone morphology,the bio-derived cancellous bone scaffold has been one of the research hotspots recently.Previous morphological study is limited to the two-dimensional level,and there are not too much research about the three-dimensional structure.So in the study,micro-CT was used to quantitatively analyze the three dimensional structure of bio-derived cancellous bone scaffolds,and to evaluate its structural parameters as bone tissue engineering scaffolds.Methods: The bio-derived bone scaffolds were obtained from fresh porcine cancellous bone after removing fat and protein.Micro-CT was used to scan and quantitatively analyze its structural parameters.The correlation coefficients were calculated by using SPSS statistical software.Results: The bio-derived bone scaffolds were obtained after derosination and deproteinization.2D and 3D images were gotten through Micro-CT scan.The results of parameters were: BV/TV(20.48±5.14) %;BS/BV(41.66±5.39) 1/mm;Porosity(79.52±5.14) %;Tb.Th(0.10±0.01) mm;Tb.N(1.99±0.47) 1/mm;Tb.Sp(0.32±0.05) mm;Tb.Pf(2.03±4.70) 1/mm;SMI(1.28±0.35);DA(1.60±0.23);Conn.Dn(158.53±106.09) 1/mm3.The statistically significant correlation coefficients were:(1)Porosity with BS/BV,Tb.Th;(2)BV/TV with BS/BV,Tb.Th;(3) BS/BV with Conn.Dn,Porosity and BV/TV;(4)Tb.Th with Porosity,BV/TV and Conn.Dn;(5)DA with Conn.Dn;(6)Conn.Dn with BS/BV,Tb.Th and DA.Conclusions: Micro-CT scanning and quantitative analysis was an ideal method to analyze scaffolds structure;It also proved that bio-derived bones scaffold meet the three-dimensional structure of bone tissue engineering requirements,especially in the pore size,porosity,bone surface/volume ratio.In addition,It could provide a reference for another scaffold preparation in the three-dimensional structure." @default.
- W2389291257 created "2016-06-24" @default.
- W2389291257 creator A5091474014 @default.
- W2389291257 date "2013-01-01" @default.
- W2389291257 modified "2023-09-24" @default.
- W2389291257 title "Quantitatively Analyze Bio-Derived Cancellous Bone Scaffolds Using Micro-CT" @default.
- W2389291257 hasPublicationYear "2013" @default.
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