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- W2389303801 abstract "Objective To explore the anti-tumor effect of isomalabaricane triterpenes (IT) in mice with transplanted subcutaneous S180 sarcoma. Methods A subcutaneous transplanted model of S180 sarcoma in mice was made. The mice were divided into five groups:blank-control,positive control,IT-high-dosage (ITH),IT-medium-dosage (ITM) and IT-low-dosage (ITL),nine mice in each group. IT (0.1,0.5,1.0 mg/L) was given to ITL,ITM and ITH,respectively,by intragastric medication,once a day; endoxam 25 mg/(kg·d) was intraperitoneally injected to the positive-control; and edible oil was lavaged for the blank-control. The medication was successive for five days,then discontinued for two days,and followed for five more days. The mice were sacrificed 24 hours after drug withdrawal. The weight of the mice and the tumors were measured. The tumor inhibition rate was calculated. Results General conditions of the mice in IT groups and the positive-control were much better than those in the blank-control,and the growth of tumor was slower,with a significant difference (F=34.786,16.407;q=3.059-16.077;P0.05). Conclusion Isomalabaricane triterpenes can inhibit the growth of subcutaneous transplanted S180 sarcoma in mice." @default.
- W2389303801 created "2016-06-24" @default.
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- W2389303801 date "2009-01-01" @default.
- W2389303801 modified "2023-09-23" @default.
- W2389303801 title "THE EFFECT OF ISOMALABARICANE TRITERPENES ON MICE WITH TRANSPLANTED S180 SARCOMA" @default.
- W2389303801 hasPublicationYear "2009" @default.
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