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- W2389306024 abstract "AIM: To study the central mechanism of intracerebral interleukin-1β in restraint stress-induced pressor response in rats. METHODS: Cardiovascular radio-telemetry system, stereotaxic microinjection system and neuroelectrophysiological methods were used to investigate the role of intracerebral interleukin-1β in pressor response induced by restraint stress, and the relation with the changes of discharge in the rostral ventrolateral medulla (RVL) neuron. RESULTS: The pressor response was induced by restraint stress and was reduced by intracerebral-ventricular injection of (icv) IL-1 receptor antagonist (IL-Ira) in conscious rats. The pressor response was directly induced by IL-1 (icv), which is related to increase of the extracellular discharge frequency in RVL neurons. CONCLUSION: Intracerebral IL-1β mediates pressor response induced by restraint stress, the mechanism may be closely related to RVL." @default.
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- W2389306024 date "2004-01-01" @default.
- W2389306024 modified "2023-09-23" @default.
- W2389306024 title "Central mechanism of intracerebral interleukin-1#beta# on pressor response induced by restraint stress" @default.
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