Matches in SemOpenAlex for { <https://semopenalex.org/work/W2389306073> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W2389306073 abstract "Objective To investigate the correlation between plasma homocysteine(Hcy)and coronary atherosclerosis,and to explore its pathogenisis mechanism.Methods The plasma levels of Hcy,vitamin B 12 ,folic acid,endothelin(ET)and serum nitric oxide(NO)were determined in 98 patients with documented coronary artery disease(CHD) and 67 controls without CHD.Gensini coronary scoring system was used to calculate coronary artery score in patients with CHD.Results (1)Plasma Hcy level was negatively related to plasma vitamin B 12 and folic acid (r=-0.407 and r=-0.338 respectively,P0.01);(2)Plasma Hcy levels in patients with CHD were higher than those in control group[(14.12±4.78)μmol/L and (9.62±2.45)μmol/L,P0.01],and there was a significantly higher incidence of hyperhomocysteinemia(14.66μmol/L)in patients with CHD than that in control group(37% and 3.5%,P0.01).A markedly positive correlation between plasma Hcy level and the number of lesion artery was observed(r=0.411,P0.01).According to multiple stepwise logistic regresion analysis,the relative ratio of Hcy to CHD was 1.28(95%CI.1.12～1.47,P0.01).(3)Plasma Hcy level was negatively related to serum NO,and positively related to plasma ET(r=0.422 and r=-0.365,respectively,P0.01).Endothelium-dependent vasodilation was impaired in the patients with hyperhomocysteinemia,compared with human without hyperhomocysteinemia[(8.86±4.33)% and (15.72±5.28)%,P0.01].Conclusion Vitamin B 12 and folic acid may influence plasma Hcy.Hyperhomocysteinemia is an risk factor for the occurrence of CHD,and its pathogenesis may be that hyperhomocysteinemia leads to the injury and dysfunction of vessel endothelium." @default.
- W2389306073 created "2016-06-24" @default.
- W2389306073 creator A5016551835 @default.
- W2389306073 date "2003-01-01" @default.
- W2389306073 modified "2023-09-24" @default.
- W2389306073 title "The correlation between plasma homocysteine and coronary lesion" @default.
- W2389306073 hasPublicationYear "2003" @default.
- W2389306073 type Work @default.
- W2389306073 sameAs 2389306073 @default.
- W2389306073 citedByCount "0" @default.
- W2389306073 crossrefType "journal-article" @default.
- W2389306073 hasAuthorship W2389306073A5016551835 @default.
- W2389306073 hasConcept C126322002 @default.
- W2389306073 hasConcept C134018914 @default.
- W2389306073 hasConcept C2776523773 @default.
- W2389306073 hasConcept C2777090595 @default.
- W2389306073 hasConcept C2778213512 @default.
- W2389306073 hasConcept C2779750884 @default.
- W2389306073 hasConcept C2992130864 @default.
- W2389306073 hasConcept C3017575891 @default.
- W2389306073 hasConcept C519581460 @default.
- W2389306073 hasConcept C71924100 @default.
- W2389306073 hasConcept C90924648 @default.
- W2389306073 hasConceptScore W2389306073C126322002 @default.
- W2389306073 hasConceptScore W2389306073C134018914 @default.
- W2389306073 hasConceptScore W2389306073C2776523773 @default.
- W2389306073 hasConceptScore W2389306073C2777090595 @default.
- W2389306073 hasConceptScore W2389306073C2778213512 @default.
- W2389306073 hasConceptScore W2389306073C2779750884 @default.
- W2389306073 hasConceptScore W2389306073C2992130864 @default.
- W2389306073 hasConceptScore W2389306073C3017575891 @default.
- W2389306073 hasConceptScore W2389306073C519581460 @default.
- W2389306073 hasConceptScore W2389306073C71924100 @default.
- W2389306073 hasConceptScore W2389306073C90924648 @default.
- W2389306073 hasLocation W23893060731 @default.
- W2389306073 hasOpenAccess W2389306073 @default.
- W2389306073 hasPrimaryLocation W23893060731 @default.
- W2389306073 hasRelatedWork W1469548897 @default.
- W2389306073 hasRelatedWork W197101018 @default.
- W2389306073 hasRelatedWork W2348088095 @default.
- W2389306073 hasRelatedWork W2350759185 @default.
- W2389306073 hasRelatedWork W2351335413 @default.
- W2389306073 hasRelatedWork W2354125021 @default.
- W2389306073 hasRelatedWork W2354740627 @default.
- W2389306073 hasRelatedWork W2357204934 @default.
- W2389306073 hasRelatedWork W2359035434 @default.
- W2389306073 hasRelatedWork W2359495816 @default.
- W2389306073 hasRelatedWork W2360540895 @default.
- W2389306073 hasRelatedWork W2363227283 @default.
- W2389306073 hasRelatedWork W2368356030 @default.
- W2389306073 hasRelatedWork W2375143939 @default.
- W2389306073 hasRelatedWork W2380804559 @default.
- W2389306073 hasRelatedWork W2381935504 @default.
- W2389306073 hasRelatedWork W2384617936 @default.
- W2389306073 hasRelatedWork W2389146085 @default.
- W2389306073 hasRelatedWork W2415234211 @default.
- W2389306073 hasRelatedWork W3029704137 @default.
- W2389306073 isParatext "false" @default.
- W2389306073 isRetracted "false" @default.
- W2389306073 magId "2389306073" @default.
- W2389306073 workType "article" @default.