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- W2389314087 abstract "The intrahepatic bile duct cells have a cytokeratin(CK) pattern different from that of hepatocytes.The latter expresses only CK18 and CK8 , but the former expresses CK19 nd CK7,in addition to CK 18 and CK8.In this research,this difference has been traced back to the early stage of development of the intrahep-atic bile ducts in rat embryos,with ABC immunohistochemical technique using different CK antibodies specif-ic for CK19 and for CK18,separately,in liver and laminin (LN)antibody. The CK19 expression was shown to be a reliable marker of biliary differentiation of the immature hepatocytes,and was believed to be an im-portant event in the morphogenesis of the bile ducts.It may be helpful for the cells to reconstruct the inter-mediate filaments- desmosome network of bile duct cell type.We also demonstrated that the CK19- positive cells had very close relation with the LN- positive basement membrane-like structure,and even more signifi-cant,the LN deposition was followed quickly by appearance of the CK19- positive cells.The close association of the two events both in their locations and in the time phases strongly indicated that LN deposition around the portal vein branches might play an important induction role in the development of the intrahepatic bile ducts in rat embryos." @default.
- W2389314087 created "2016-06-24" @default.
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- W2389314087 date "1994-01-01" @default.
- W2389314087 modified "2023-09-23" @default.
- W2389314087 title "Mechanism oh the morphogenesis of the intrahepatic bile ducts in rat embryos, a cytokeratin-and laminin-immunohistochemical study" @default.
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