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- W2389320910 abstract "Objective To investigate the dissemination of cryptococcal infection after skin inoculation of cryptococcus neoformans and explore the possibility of skin as the route of entry into host by cryptococcus neoformans.Methods Immunocompromised Balb/C mouse model was made by administrating cyclophosphamide(CTX).Balb/C mice,either immunocompromised or immunocompe- tent,were intradermaly inoculated with wild type cryptococcus neoformans variety neoformans B3501 or variety gattii ATCC32609.One,two,four weeks after the infection lesions appears, mycological culture was performed with liver,spleen,kidney,heart,brain and blood of the mice and latex agglutination test of cryptococcus antigen(LAT)was clone with serum of the mice.Results Mean time of lesion appearance was 3.42 d in immunocompromised mice,4.25 d in immunocompenent mice(P0.05).Mean time for lesion healing in immunocompromised and immunocompenent mice was 36.8 d and 29.0 d respectively(P0.05).Mycological tests were done with viscera tissues and blood samples at 1,2 and 4 weeks after the lesion development.The culture results were all negative, while the positive rate of LAT was 50.0% in B3501 group and 16.7% in ATCC32609 group(P0.05).Conclusions Primary cutaneous cryptococcosis may lead to dissemination of the infection in immunocompromised mice and our data suggest that skin is a possible route for dissemination of cryptococcal infection." @default.
- W2389320910 created "2016-06-24" @default.
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- W2389320910 date "2007-01-01" @default.
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- W2389320910 title "Dissemination of primary cutaneous cryptococcosis in Balb/C mice" @default.
- W2389320910 hasPublicationYear "2007" @default.
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