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- W2389322017 abstract "[Objective] To study the expressions of PTEN and TGF-β1 in different endometria tissues, and to analyze their role in endometrial carcinoma. [Methods] Selected 90 cases of endometria specimen from the first people′s hospital during the year of 1995-2005, including 47 cases of endometrial carcinoma,24 cases of endometrial hyperplasia and 19 cases of normal endometrium. Immunohistochemical method was used to detect the expression of PTEN and TGF-β1 in endometria tissue. All data was analyzed with SPSS11.0 statistics software, and chi-square test was used for statistic and analysis. [Results] The negtive expression rate of PTEN in normal endometrium, endometrial hyperplasia and endometrial carcinoma were 10.53%, 54.17% and 70.21%. The rats were higher in endometrial hyperplasia and endometrial carcinoma than in normal endometrium(P 0.005). The positive expression rates of TGF-β1 were 94.74%, 70.83% and 68.09%. The difference was not statistically significant (P 0.05) in the previous three groups. The negtive expression rate of PTEN protein was not related to cytodifferentiation degree (P 0.05). But the positive expression rate of TGF-β1 was higher in well-differentiated group than in poorly differentiated group (P 0.05). When PTEN protein was negtive expressed, the positive expression rate of TGF-β1 was 72.73%; When PTEN protein was positive expressed, the positive expression rate of TGF-β1 was 57.14%. There was no statistically significance (P 0.05). [Conclusions] The loss expression of anti-oncogene PTEN is relaed with the morbility of endometrial carcinoma. The higher cytodifferentiation degree, the higher positive expression rate of TGF-β1. The former is not related with the negtive expression of PTEN." @default.
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- W2389322017 date "2007-01-01" @default.
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- W2389322017 title "Expression of PTEN and TGF-β1 in endometrial carcinoma and its significance" @default.
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