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- W2389332250 abstract "Objective To investigate the effect of NHE and its inhibitor in acute lung injury.Methods Used Lipopolysaceharide(LPS,5 mg/kg)to reproduct the model of acute lung injury in rats.Twenty-one adult SD rats (170～230 g)were divided averagely into three group as follow:control group;LPS group;DMA pretreative group.After five hours,killed the rats all.And then,calculated the lung index,and detected the concentration of TNF、ET-1 and NO in the blood and the bronchealveolar lavage fluid(BALF).Result Compared with the LPS group,elevation of the LI and the concentration of the cytokines(such as TNF、ET-1 and NO)in the blood and the BALF was eventurely less in the DMA pretreative group( P 0 01).Conclusion The NHE inhibitor can protect acute lung injury,and NHE involves in acute lung injury exactly. [" @default.
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- W2389332250 title "Effect of NHE and its inhibitor in acute lung injury" @default.
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