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- W2389333481 abstract "Objective To investigate the effects of three doses(10 mg,20 mg,40 mg) of simvastatin on blood fat and blood vessel endothelium function of elderly coronary artery disease patients.Methods 106 elderly coronary artery diaease patients were enrolled in this study(male 68,female 38)and divided into 3 groups randomly:group A,n=53(male 34,female 19),group B,n=51(male 33,female 18),group C,n=52(male 33,female 19),group D(control group),n=40(male 26,female 14).The patients of group A,B,and C were administrated 10 mg,20 mg,40 mg simvastatin by mouth one time per day,respectively.Brachial artery endothelium-dependent diastolic function mediated by blood flow was determined through super sound method and change of blood fat level was observed at the same time.Results After administrated,the levels of TC and LDL-C in group A,B,C were significantly lower than that before administrated(P0.05).Among group A,B,C,the levels of TC and LDL-C at 4,8,12,24 weeks after administrated were significantly different(P0.05).Group cGroup BGroup A.The levels of TC and LDL-C of group A,B,C at 4 weeks after administrated decreased obviously.Following the administration time,the levels of TC and LDL-C continued to decrease and at 12 weeks,they reached peak and maintained effective level at 24 weeks.Simvastatin decreased the levels of TC and LDL-C dose-dependently.Simvastatin may significantly improve blood vessel endothelium function of elderly coronary artery disease.Before administrated,FMD of group A,B,C were significantly lower than that of control group(group D)(P0.05).After administrated,FMD of these groups were significantly higher than that before administrated(P0.05).In group A,FMD at 4,8,12,24 weeks after administrated increased by24%,47%,74%,100%,respectively.In group B,FMD at 4,8,12,24 weeks after administrated increased by 48%,61%,97%,90%,respectively.In group C,FMD at 4,8,12,24 weeks after administrated increased by 47%,68%,116%,141%,respectively.FMD was not different among group A,B and C(P0.05).Conclusion At 4 weeks after administrated simvastatin,the levels of TC and LDL-C significantly decrease and blood vessel endothelium function is improved.Long administration can adjust fat and continue improving blood vessel endothelium function 20 mg/d of simvastatin is the best option for elderly hyperlipemia.Different dose of simvastatin all can significantly improve FMD of elderly coronary artery disease patients,the improvement degree is not different,because independent of adjusting fat." @default.
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- W2389333481 date "2008-01-01" @default.
- W2389333481 modified "2023-09-24" @default.
- W2389333481 title "The effects of three doses of simvastatin on blood fat and blood vessel endothelium function of elderly coronary artery disease patients" @default.
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