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- W2389338065 abstract "Objective To explore the efficacy and safety of paroxetine with small-dose trazodone in the treatment of depression with erectile dysfunction. Methods 101 patients with the diagnosis of depression with erectile dysfunction were randomly divided into experimental group(n=50)and control group(n=51). It was treated for paroxetine with small-dose trazodone in experimental group. The control group was treated with paroxetine for 6 weeks. The clinical efficacy, erectile function and side effects were evaluated with HAMD, IIEF-5 and TESS before treatment and 1、2、4、6 weeks after treatment respectively. Results In the treatment of depression symptoms, the significant improvement rate of experimental group was 86.0%, that of control group was 78.4%. There was no significant difference between two groups in efficacy. The scores of HAMD 1 and 2 weeks after treatment in the experimental group were significant lower than those in the control group(P0.05). In the treatment of ED, the significant improvement rate of both groups was 56.0% in experimental group and 21.6% in control group, respectively(P0.01). The scores of IIEF-5 from 4th week in the experimental group were significant higher than those in the control group. The improvement of ED was positively correlated with the reductive scores of retardation. But there was no difference in TESS between two groups. Conclusions Paroxetine with small-dose trazodone showed rapidly response in the treatment of depression symptom, and significantly improved the erectile dysfunction than paroxetine, and with less side effects." @default.
- W2389338065 created "2016-06-24" @default.
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- W2389338065 date "2006-01-01" @default.
- W2389338065 modified "2023-09-23" @default.
- W2389338065 title "A comparative study of paroxetine with small-dose trazodone in the treatment of depression with erectile dysfunction" @default.
- W2389338065 hasPublicationYear "2006" @default.
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