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- W2389342386 abstract "Objective To investigate the relationship between expression of metastasis suppressor genes KISS1,KAI1and FHL1 and lymph node metastasis in breast cancer.Methods Tissue microarray and immunohistochemistry by EnVision methods were employed to study 59 archival breast carcinoma samples and 31 noncancerous tissue samples.The presence of KISS1,KAI1 and FHL1 protein were investigated in relation to lymph node metastasis.Results ① The expressions of KISS1,KAI1 and FHL1 were insignificantly different between breast cancer tissue group and noncancerous tissue group(P0.05);② The expressions of KISS1,KAI1 and FHL1 were negatively related to axillary lymph node metastasis and clinica1 stage(P0.05),but were not statistically correlated with age and tumor size in breast carcinoma tissues(P0.05);the expressions of KISS1 and KAI1 were positively related to P53(P0.05) and the expression of KAI1 was positively related to ER and PR(P0.05);the expressions of FHL1 were negatively related to PR(P0.05).③ The expressions of KISS1,KAI1 and FHL1 were positively related to each other(P0.01).Conclusions The low?expressions of KISS1,KAI1 and FHL1 are closely correlated with the tumor invasion and metastasis of breast carcinoma.Detecting these indexes can be helpful in assessment of the invasional and biological behaviors of breast carcinoma." @default.
- W2389342386 created "2016-06-24" @default.
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- W2389342386 date "2010-01-01" @default.
- W2389342386 modified "2023-09-26" @default.
- W2389342386 title "Expressions of KISS1、KAI1 and FHL1 and neoplasms metastasis" @default.
- W2389342386 hasPublicationYear "2010" @default.
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