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- W2389345103 abstract "Objective To study the effects of mitogen activated protein kinase(MAPK) inhibitor PD98059 on mRNA expression of Bcl-2 and Caspases-3 in NRK cells treated with cadmium chloride(CdCl2).Methods Cell apoptosis was tested in NRK cells treated with CdCl2 for 6 hr with flow cytometer.Nature kill(NRK) cells were pretreated with MAPK inhibitor PD98059 for 1 hr,then treated with various doses of CdCl2.Real-time flourescent quantitative PCR was applied to monitor the mRNA expression of Bcl-2 and Caspase-3 in NRK cells after the treatment.Results CdCl2 induced dose-dependent apoptosis in NRK cells,and a decrease in Bcl-2 mRNA expression as well as an increases in Capsase-3 mRNA expression.Pretreatment of NRK cells with MAPK inhibitor PD98059 blocked effects of cadntium on Bcl-2 mRNA expression deerease and Caspase-3 mRNA expression increase.Conclusion MAPK inhibitor PD98059 could interfere with the effects of CdCl2 on Bcl-2 and Caspase-3 mRNA expression in NRK cells.The results indicated MAPK signal pathway might be involved in cadmuim-induced apoptosis." @default.
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- W2389345103 date "2009-01-01" @default.
- W2389345103 modified "2023-09-24" @default.
- W2389345103 title "Effects of MAPK inhibitor on mRNA expression of Bcl-2 and Caspases-3 in NRK cells treated with cadmium chloride" @default.
- W2389345103 hasPublicationYear "2009" @default.
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